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Invitrogen
TET2 Polyclonal Antibody
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TET2 Antibody (PA5-35847) in WB
Western blot analysis of TET2 using A) 30 µg 293T whole cell lysate and B) 30 µg whole cell lysate of human TET2-transfected 293T cells. Samples were loaded onto a 5% SDS-PAGE gel and probed with a TET2 polyclonal antibody (Product # PA5-35847) at a dilution of 1:1000.
产品信息
PA5-35847
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 429 and 637 of TET2
偶联物
形式
Liquid
浓度
0.88 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient
RRID
产品详细信息
Recommended positive controls: TET2-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2's role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
