Proteintech

TFAP2B Polyclonal Antibody

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TFAP2B Polyclonal Antibody

产品信息

13183-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
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免疫沉淀 (IP)

0.5-4.0 µg
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

TFAP2B Fusion Protein Ag3853 (111-460 aa encoded by BC037225)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.18 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: RQEVGSEAG SLLPQPRAAL PQLSGLDPRR DYHSVRRPDV LLHSAHHGLD AGMGDSLSLH GLGHPGMEDV QSVEDANNSG MNLLDQSVIK KVPVPPKSVT SLMMNKDGFL GGMSVNTGEV FCSVPGRLSL LSSTSKYKVT VGEVQRRLSP PECLNASLLG GVLRRAKSKN GGRSLRERLE KIGLNLPAGR RKAANVTLLT SLVEGEAVHL ARDFGYICET EFPAKAVSEY LNRQHTDPSD LHSRKNMLLA TKQLCKEFTD LLAQDRTPIG NSRPSPILEP GIQSCLTHFS LITHGFGAPA ICAALTALQN YLTEALKGMD KMFLNNTTTN RHTSGEGPGS KTGDKEEKHR K (111-460 aa encoded by BC037225)

靶标信息

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: activating enhancer binding protein 2 beta; activating enhancer-binding protein 2 beta; Activating enhancer-binding protein 2-beta; AP2-beta; transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Transcription factor AP-2-beta

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基因别名: AI606113; AP-2(beta); AP-2B; AP2-B; E130018K07Rik; Tcfap2b; TFAP2B

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UniProt ID: (Human) Q92481, (Mouse) Q61313

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Entrez Gene ID: (Human) 7021, (Mouse) 21419, (Rat) 301285

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功能
RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity RNA polymerase II transcription corepressor activity enhancer sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process sequence-specific DNA binding protein heterodimerization activity protein dimerization activity RNA polymerase II regulatory region sequence-specific DNA binding general transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter kidney development renal water homeostasis glucose metabolic process regulation of transcription, DNA-templated transcription from RNA polymerase II promoter apoptotic process positive regulation of cell proliferation negative regulation of cell proliferation response to lithium ion retina layer formation magnesium ion homeostasis regulation of BMP signaling pathway forelimb morphogenesis hindlimb morphogenesis positive regulation of urine volume aorta morphogenesis response to drug glucose homeostasis negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process skin development fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development regulation of insulin secretion phosphate ion homeostasis calcium ion homeostasis potassium ion homeostasis sodium ion homeostasis distal tubule development collecting duct development metanephric nephron development ductus arteriosus closure cellular ammonia homeostasis cellular creatinine homeostasis cellular urea homeostasis transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of cell proliferation anatomical structure development
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