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Rockland
TGF beta Receptor 1 Polyclonal Antibody
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TGF beta Receptor 1 Antibody (600-401-MG6) in IHC
Immunohistochemistry of Rabbit Anti-TGF beta Receptor 1 Antibody. Tissue: human pancreas. Antigen retrieval: HIER using Citrate Buffer for 20min. Primary Antibody: TGF beta receptor 1 at 1:100 for 30min at room temperature. Secondary Antibody: Anti-Rabbit Poly-HRP-IgG Ready-to-use for 8 min at room temperature. Staining: DAB. Counterstain: Hematoxylin.
产品信息
600-401-MG6
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-TGF beta receptor 1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of human TGF beta receptor 1 conjugated to Keyhole Limpet Hemocyanin (KLH).
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Directed against human TGF beta receptor type-1 protein. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse, rat, bovine, and wild boar. Cross-reactivity is expected with TGFb1 from non-mammalian sources as only a single amino acid residue change is found within the immunogen sequence from many other organisms.
靶标信息
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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