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Invitrogen
TIMP1 Polyclonal Antibody
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产品信息
PA1-25310
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the first loop domain of human TIMP1.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
PA1-25310 detects TIMP1 from human samples. This antibody does not cross-react with other TIMP family members..
PA1-25310 has been successfully used in immunohistochemistry (frozen) immunoprecipitation, and Western blot procedures. By Western blot, this antibody detects a 29 kDa band from reduced samples. Please note that TIMP1 is expressed in low (pg/ml) levels in most cell types. Treatment of cells with a phorbol ester (ie. PMA) stimulates production fo TIMP1 in some cell types, but concentration of cell culture media may still be necessary to visualize bands in WB.
The PA1-25310 immunogen is a synthetic peptide corresponding to the first loop domain of human TIMP1.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
靶标信息
TIMP1 (metalloproteinase inhibitor 1) is a metalloproteinase inhibitor that functions by forms one-to-one complexes with target metallproteinases, such as collagenases, and irreversible inactivates them by binding to their catalytic zinc cofactor. TIMP1 acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP14, and MMP16. It also functions as a growth factor that regulates cell differenation, migration, and cell death. TIMP1 activates cellular signaling cascades via CD63 and ITGB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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