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Invitrogen
TIMP2 Polyclonal Antibody
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产品信息
PA5-94943
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP2 (205-220aa RGAAPPKQEFLDIEDP).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - IHC: Human Mammary Cancer Tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CSC-21K; Metalloproteinase inhibitor 2; testicular secretory protein Li 57; TIMP 2; TIMP-2; tissue inhibitor of metalloproteinase 2; Tissue inhibitor of metalloproteinases 2
基因别名: CSC-21K; D11Bwg1104e; DDC8; Timp-2; TIMP2
UniProt ID: (Human) P16035, (Rat) P30121
Entrez Gene ID: (Human) 7077, (Rat) 29543, (Mouse) 21858
central nervous system development
aging
negative regulation of cell proliferation
response to hormone
negative regulation of endopeptidase activity
extracellular matrix disassembly
regulation of Rap protein signal transduction
response to cytokine
response to drug
positive regulation of MAPK cascade
positive regulation of neuron differentiation
positive regulation of adenylate cyclase activity
negative regulation of mitotic cell cycle
negative regulation of Ras protein signal transduction
negative regulation of membrane protein ectodomain proteolysis
spermatogenesis
regulation of cAMP metabolic process
positive regulation of catalytic activity
negative regulation of catalytic activity
regulation of MAPK cascade
regulation of neuron differentiation
negative regulation of proteolysis
cellular response to organic substance
negative regulation of peptidase activity
