Progen

TKTL1 Monoclonal Antibody (VU-7H2-G5-C1)

Name: TKTL1 Monoclonal Antibody (VU-7H2-G5-C1)
Brand: Progen
SKU: 610175PROGEN

查看其他6个TKTL1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image TKTL1 Monoclonal Antibody (VU-7H2-G5-C1)

产品信息

610175PROGEN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200

免疫组化（石蜡） (IHC (P))

1:50

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

VU-7H2-G5-C1

抗原

Hplc Purified Peptide From Tktl1

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.05 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 0.5% BSA

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute lyophilized product with 1 mL distilled water.

Expression studies on transketolase-like-1 show that the protein is found in aggressive tumors. The detection of TKTL1 is furthermore correlated with poor patient prognosis and metastasis. Transketolase dependent reactions regulate the non-oxidative part of the pentose-phosphate-pathway (PPP) in glucose metabolism. This pathway generates NADPH and pentose phosphates. The latter are important for nucleic acid metabolism. Beside the ubiquitous transketolase (TKT) other transketolase-like proteins exist. Transketolase-like 1 (TKTL1) is a protein with a 38 amino acid deletion when compared to TKT. TKTL1 expression has been shown in tumors of different entities. Inhibition of TKTL1 expression by RNA interference results in reduced growth of tumor cells, while overexpression of TKTL1 promotes cell proliferation. Recent publications suggest an important role of TKTL1 in the metabolism of tumor cells. In colorectal tumors nuclear as well as cytoplasmic localization has been described.Reactivity on cultured cell lines: THP-1.

靶标信息

Strong TKTL1 protein expression has been correlated with a certain type of glucose metabolism (aerobic glycolysis; Warburg effect) and to cells which are affected by chronic complications of diabetic patients. In colon and urothelial carcinomas, expression at the protein level is correlated with invasiveness of tumors and poor patient survival.

仅用于科研。不用于诊断过程。未经明确授权不得转售。