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Abnova
TM6SF2 Polyclonal Antibody, MaxPab™
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Product Details
H00053345-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TM6SF2 (AAI60089.1, 1 a.a. approximately 377 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDIPPLAGKI AALSLSALPV SYALNHVSAL SHPLWVALMS ALILGLLFVA VYSLSHGEVS YDPLYAVFAV FAFTSVVDLI IALQEDSYVV GFMEFYTKEG EPYLRTAHGV FICYWDGTVH YLLYLAMAGA ICRRKRYRNF GLYWLGSFAM SILVFLTGNI LGKYSSEIRP AFFLTIPYLL VPCWAGMKVF SQPRALTRCT ANMVQEEQRK GLLQRPADLA LVIYLILAGF FTLFRGLVVL DCPTDACFVY IYQYEPYLRD PVAYPKVQML MYMFYVLPFC GLAAYALTFP GCSWLPDWAL VFAGGIGQAQ FSHMGASMHL RTPFTYRVPE DTWGCFFVCN LLYALGPHLL AYRCLQWPAF FHQPPPSDPL ALHKKQH
Target Information
The TM6SF2 gene encodes transmembrane 6 superfamily member 2, a protein implicated in lipid metabolism and liver function. TM6SF2 is predominantly expressed in the liver and plays a crucial role in the regulation of lipid homeostasis, affecting the secretion of triglycerides and cholesterol. Genetic variations in TM6SF2, particularly the E167K polymorphism, have been associated with non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases. This variant influences lipid metabolism by altering the balance between lipid storage and secretion, contributing to hepatic steatosis and the progression of liver disease. Additionally, TM6SF2 mutations impact the risk of atherosclerosis due to their effects on lipid profiles, highlighting its significance in metabolic diseases. Research into TM6SF2 continues to uncover its roles in regulating lipid transport and metabolism, making it a potential target for therapeutic strategies addressing liver and cardiovascular health.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Transmembrane 6 superfamily member 2
Gene Aliases: TM6SF2
UniProt ID: (Human) Q9BZW4
Entrez Gene ID: (Human) 53345
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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