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Fabgennix
TM6SF2 Polyclonal Antibody
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TM6SF2 Antibody (TM6SF2-201AP) in WB
Western Blot using TM6SF2 Antibodies (TM6SF2-201AP & TM6SF2-212AP) : 1. Empty Vehicle 2. Recominant Mouse TM6SF2 3. Empty Vehicle 4. Recombinant Human TM6SF2 Primary antibody TM6SF2-201AP and TM6SF2-212AP diluted 1:500 in DiluOBuffer. TM6SF2-201AP was used on lanes 1 and 2. TM6SF2-212AP was used on lanes 1 and 3.
产品信息
TM6SF2-201AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 220-270 on mouse TM6SF2 protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The TM6SF2 gene encodes transmembrane 6 superfamily member 2, a protein implicated in lipid metabolism and liver function. TM6SF2 is predominantly expressed in the liver and plays a crucial role in the regulation of lipid homeostasis, affecting the secretion of triglycerides and cholesterol. Genetic variations in TM6SF2, particularly the E167K polymorphism, have been associated with non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases. This variant influences lipid metabolism by altering the balance between lipid storage and secretion, contributing to hepatic steatosis and the progression of liver disease. Additionally, TM6SF2 mutations impact the risk of atherosclerosis due to their effects on lipid profiles, highlighting its significance in metabolic diseases. Research into TM6SF2 continues to uncover its roles in regulating lipid transport and metabolism, making it a potential target for therapeutic strategies addressing liver and cardiovascular health.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Transmembrane 6 superfamily member 2
基因别名: TM6SF2
UniProt ID: (Human) Q9BZW4, (Mouse) Q8R1J1, (Rat) B0BNG2
Entrez Gene ID: (Human) 53345, (Mouse) 107770, (Rat) 689029
