Proteintech

TMEM24 Polyclonal Antibody

Name: TMEM24 Polyclonal Antibody
Brand: Proteintech
SKU: 25507-1-AP

查看其他6个TMEM24抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

TMEM24 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 3

TMEM24 Antibody (25507-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using (Product # 25507-1-AP) (TMEM24 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Immunogen image

Immunogen Image TMEM24 Polyclonal Antibody

产品信息

25507-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:200

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

TMEM24 Fusion Protein Ag21913 (1-350 aa encoded by BC022219)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.29 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody detects TMEM24 protein with MW 70-100 kDa.

Immunogen sequence: MDPGWGQRD VGWAALLILF AASLLTVFAW LLQYARGLWL ARARGDRGPG PALAGEPAGS LRELGVWRSL LRLRATRAGA AEEPGVRGLL ASLFAFKSFR ENWQRAWVRA LNEQACRNGS SIQIAFEEVP QLPPRASISH VTCVDQSEHT MVLRCQLSAE EVRFPVSVTQ QSPAAVSMET YHVTLTLPPT QLEVNLEEIP GEGLLISWAF TDRPDLSLTV LPKLQARERG EEQVELSTIE ELIKDAIVST QPAMMVNLRA CSAPGGLVPS EKPPMMPQAQ PAIPRPNRLF LRQLRASHLG NELEGTEELC CVAELDNPMQ QKWTKPARAG SEVEWTEDLA LDLGPQSREL T (1-350 aa encoded by BC022219)

靶标信息

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。