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Invitrogen
TMEM38A Polyclonal Antibody
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TMEM38A Antibody (PA5-77754) in ICC/IF
Immunocytochemistry analysis of TMEM38A in paraformaldehyde-fixed and permeabilized mouse muscle myoblast cell line. A) Samples were probed with TMEM38A polyclonal antibody (Product # PA5-77754) at a dilution of 1:200, and incubated with goat-anti-rabbit-AlexaFluor-594 and DAPI. B) Nuclei stained image. C) Merged images of Panels A and B.
产品信息
PA5-77754
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide (C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259-274 of rat
偶联物
形式
Lyophilized
浓度
0.9 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
靶标信息
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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