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Invitrogen
TMPRSS11B Polyclonal Antibody
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产品信息
PA5-31481
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the Extracellular domain of human TMPRSS11B. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: A549, HeLa, HCT116.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
TMPRSS11B, a member of the transmembrane serine protease family, has recently gained attention for its role in promoting tumor growth, particularly in lung squamous cell carcinomas (LSCCs). This gene is located on chromosome 4q13.2 and encodes a protein involved in proteolytic processing of substrates, impacting cellular communication and tissue homeostasis. TMPRSS11B is upregulated in LSCCs, and its high expression correlates with poor survival rates in non-small cell lung cancer patients. Research has demonstrated that TMPRSS11B facilitates metabolic reprogramming in cancer cells, aiding their transformation and proliferation. In vitro studies with immortalized human bronchial epithelial cells have shown that TMPRSS11B enhances tumor growth, indicating its potential as a therapeutic target for lung cancer treatment. Moreover, TMPRSS11B depletion in immunocompetent mice led to reduced tumor burden and increased infiltration of immune cells, suggesting its influence on the tumor microenvironment.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Airway trypsin-like protease 5; Transmembrane protease serine 11B
基因别名: HATL5; TMPRSS11B
UniProt ID: (Human) Q86T26
Entrez Gene ID: (Human) 132724
