Proteintech

TNIK Polyclonal Antibody

Name: TNIK Polyclonal Antibody
Brand: Proteintech
SKU: 13955-1-AP

查看其他17个TNIK抗体

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

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TNIK Antibody (13955-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 13955-1-AP (TNIK antibody) at dilution of 1:1,500 incubated at room temperature for 1.5 hours.

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产品信息

13955-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

酶联免疫吸附实验 (ELISA)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

TNIK fusion protein Ag5068

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

400 µg/mL

60 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Sequence of this protein is as follows: PRVYQTSPTD EDEEDEESSA TALFTSELLR QEQAKLNEAR KISVVNVNPT NIRPHSDTPE IRKYKKRFNS EILCAALWGV NLLVGTENGL MLLDRSGQGK VYNLINRRRF QQMDVLEGLN VLVTISGKKN KLRVYYLSWL RNRILHNDPE VEKKQGWITV GDLEGCIHYK VVKYERIKFL VIALKNAVEI YAWAPKPYHK FMAFKSFADL QHKPLLVDLT VEEGQRLKVI FGSHTGFHVI DVDSGNSYDI YIPSHIQGNI TPHAIVILPK TDGMEMLVCY EDEGVYVNTY GRITKDVVLQ WGEMPTSVAY IHSNQIMGWG EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC ERNDKVFFAS VRSGGSSQVF FMTLNRNSMM NW

靶标信息

TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton.

仅用于科研。不用于诊断过程。未经明确授权不得转售。