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Invitrogen
TNK1 Polyclonal Antibody
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产品信息
PA5-100919
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TNK1(Accession Q13470), corresponding to amino acid residues L251-S301.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total TNK1.
靶标信息
TNK1 tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family and as such is an important regulator of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in a few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD38 negative kinase 1; Kinase of embryonic stem cells; MGC46193; non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase, non-receptor 1; tyrosine kinase, non-receptor, 1
基因别名: Kos1; TNK1; Tnk1a; Tnk1b
UniProt ID: (Human) Q13470, (Mouse) Q99ML2
Entrez Gene ID: (Human) 8711, (Mouse) 83813
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
receptor binding
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
hormone receptor binding
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
cell differentiation
negative regulation of cell growth
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
negative regulation of Ras protein signal transduction
protein autophosphorylation
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
