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Invitrogen
TNPO2 Polyclonal Antibody
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产品信息
PA5-67176
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QDIKPRFHKSR TVTLPHEAER PDGSEDAEDD DD
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 97%.
靶标信息
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: importin 3; karyopherin beta 2b, transportin; Karyopherin beta-2b; transportin 2 (importin 3, karyopherin beta 2b); Transportin-2
基因别名: IPO3; KPNB2B; TNPO2; TRN2
UniProt ID: (Human) O14787
Entrez Gene ID: (Human) 30000
