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Invitrogen
TNPO3 Polyclonal Antibody
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产品信息
PA5-65303
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human TNPO3
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: RSLDSFLLSPE AAVGLLKGTA LVLARLPLDK ITECLSELCS VQVMALKKLL SQEPSNGISS DPTVFLDRLA VIFRHTNPIV ENGQTHPCQK VIQEIWPVLS ETLNKHRAD
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.
靶标信息
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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