Invitrogen

TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)

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说明书
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TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)

产品信息

703809

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
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免疫组织化学（多聚甲醛固定） (IHC (PFA))

-
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免疫细胞化学 (ICC/IF)

1:100
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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

10H7L17

抗原

Protein corresponding to human TP63 [aa360-aa500]
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2809251

产品详细信息

This antibody is predicted to react with Monkey, Mouse, Rat, Bovine.

靶标信息

TP63 (tumor protein 63) acts as a sequence-specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform-specific activity. Isoform 2 activates RIPK4 transcription. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by inducing JAG1 and JAG2. TP63 plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. TP63 is required for limb formation from the apical ectodermal ridge. It also activates transcription of the p21 promoter. Mutations affecting the gene can result in Acro-dermato-ungual-lacrimal-tooth syndrome, ankyloblepharon-ectodermal defects-cleft lip/palate, ectrodactyly ectodermal dysplasia, split-hand/foot malformation 4, limb-mammary syndrome, ectodermal dysplasia - Rapp-Hodgkin type, and orofacial cleft 8.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: amplified in squamous cell carcinoma; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; p40; p51; p63; p63a; p73L; TP63; Transformation-related protein 63; Tumor protein 63; tumor protein p53-competing protein; Tumor protein p73-like

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基因别名: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L

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UniProt ID: (Human) Q9H3D4

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Entrez Gene ID: (Human) 8626

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功能
transcription factor activity, transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding WW domain binding P53-like transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter replicative cell aging skeletal system development establishment of planar polarity positive regulation of mesenchymal cell proliferation epithelial cell development chromatin remodeling transcription from RNA polymerase II promoter apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Notch signaling pathway spermatogenesis ectoderm and mesoderm interaction proximal/distal pattern formation response to X-ray multicellular organism aging response to gamma radiation epidermal cell division regulation of epidermal cell division positive regulation of keratinocyte proliferation keratinocyte differentiation embryonic limb morphogenesis polarized epithelial cell differentiation hair follicle morphogenesis mitotic G1 DNA damage checkpoint cellular response to UV post-anal tail morphogenesis odontogenesis of dentin-containing tooth intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process negative regulation of apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of neuron apoptotic process skin morphogenesis keratinocyte proliferation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development smooth muscle tissue development female genitalia morphogenesis protein homotetramerization neuron apoptotic process urinary bladder development cloacal septation prostatic bud formation squamous basal epithelial stem cell differentiation involved in prostate gland acinus development establishment of skin barrier positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator positive regulation of fibroblast apoptotic process negative regulation of mesoderm development
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