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Invitrogen
TPM1 Monoclonal Antibody (CH1)
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产品信息
MA5-11783
应用
建议稀释比
已发表文章
产品规格
种属反应
Chicken,
Human,
Rat
已发表种属
Human,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
CH1
抗原
Tropomyosin protein purified from chicken embryo fibroblasts (CEF) and chicken leg, heart, and gizzard
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-11783 targets Tropomyosin in IF and IHC (P) applications and shows reactivity with Chicken, Human, and Rat samples.
The MA5-11783 immunogen is tropomyosin protein purified from chicken embryo fibroblasts (CEF) and chicken leg, heart, and gizzard.
靶标信息
Tropomyosin is a dimeric coiled-coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified as such by their different apparent molecular masses after separation by SDS-PAGE, but similar biochemical properties, such as resistance to heat and organic solvents, the ability to bind to F-actin filaments, and the lack of proline and tryptophan.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alpha tropomyosin of brain; alpha tropomyosin of fibroblasts F2; alpha-Tm-1; alpha-Tm-2 isoform; Alpha-tropomyosin; alpha-tropomyosin (partial); alpha-tropomyosin 1; alpha-tropomyosin 2; alpha-tropomyosin of skeletal fast muscle; cardiomyopathy, hypertrophic 3; epididymis secretory protein Li 265; hepatoma alpha tropomyosin; myofibrillar protein; component of thin filaments; alternatively spliced; sarcomeric tropomyosin kappa; skeletal muscle tropomyosin; smooth muscle alpha-tropomyosin; striated muscle alpha-tropomyosin; TPM1-alpha; tropomyosin; tropomyosin (CTm4); tropomyosin (CTm7); tropomyosin 1 (alpha); tropomyosin 1 (alpha) isoform TPM1_1; tropomyosin 1 (alpha) isoform TPM1_2; tropomyosin 3 alpha; Tropomyosin alpha-1 chain; Tropomyosin-1; unnamed protein product
基因别名: alpha-fTM; Alpha-tm; C15orf13; CMD1Y; CMH3; HEL-S-265; HTM-alpha; LVNC9; Tma2; TMSA; TPM1; Tpma; tropomyosin-1
UniProt ID: (Chicken) P04268, (Human) P09493, (Rat) P04692
Entrez Gene ID: (Chicken) 396366, (Human) 7168, (Rat) 24851
protein binding
cytoskeletal protein binding
identical protein binding
protein homodimerization activity
protein heterodimerization activity
actin filament binding
actin binding
structural constituent of cytoskeleton
structural constituent of muscle
protein N-terminus binding
actin binding motor protein
muscle contraction
actin filament organization
cardiac muscle contraction
positive regulation of heart rate by epinephrine
regulation of muscle contraction
cytoskeleton organization
regulation of heart contraction
regulation of cell shape
muscle filament sliding
negative regulation of cell migration
ruffle organization
cellular response to reactive oxygen species
wound healing
sarcomere organization
positive regulation of cell adhesion
positive regulation of stress fiber assembly
ventricular cardiac muscle tissue morphogenesis
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
in utero embryonic development
positive regulation of ATPase activity
regulation of ATPase activity
actin filament capping
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