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Abnova
TPT1 Monoclonal Antibody (2A3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00007178-M06
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
2A3
抗原
TPT1 (AAH22436, 35 a.a. approximately 138 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: GVDIVMNHHL QETSFTKEAY KKYIKDYMKS IKGKLEEQRP ERVKPFMTGA AEQIKHILAN FKNYQFFIGE NMNPDGMVAL LDYREDGVTP YMIFFKDGLE MEKC
靶标信息
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 21 kDa polypeptide under translational control; fortilin; histamine-releasing factor; lens epithelial protein; TCTP; TPT1; translationally regulated transcript (21 kDa); unnamed protein product
基因别名: HRF; p02; p21; p23; TCTP; Trt
UniProt ID: (Human) P13693, (Rat) P63029, (Mouse) P63028
Entrez Gene ID: (Human) 7178, (Rat) 116646, (Mouse) 22070
spermatogenesis
response to virus
negative regulation of autophagy
stem cell population maintenance
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of ectoderm development
negative regulation of apoptotic signaling pathway
calcium ion transport
cellular calcium ion homeostasis
regulation of apoptotic process
negative regulation of apoptotic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
