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Invitrogen
TRADD Polyclonal Antibody
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TRADD Antibody (PA5-71607) in ICC/IF
Immunofluorescent analysis of TRADD in HeLa cells using confocal microscopy. Samples were incubated with TRADD H1 polyclonal antibody (Product # PA5-71607) followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) as a secondary antibody. Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
产品信息
PA5-71607
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human TRADD
偶联物
形式
Liquid
浓度
0.36 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
靶标信息
TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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