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Invitrogen
TRAIL-R2 (DR5) Humanized Recombinant Human Monoclonal Antibody (TAS266)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-54815
产品规格
种属反应
Human
宿主/亚型
Human
/ VH-VH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
TAS266
抗原
Recombinant Human CD262/TNFRSF10B/TRAIL-R2/DR5.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
Isotype of this product is: (VHH-VHH-hFc)-dimer
靶标信息
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD262; Death receptor 5; dr-5; sCD262; soluble CD262; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; Tumor necrosis factor receptor superfamily member 10B
基因别名: DR5; KILLER; TNFRSF10B; TRAILR2; TRICK2; UNQ160/PRO186; ZTNFR9
Entrez Gene ID: (Human) 8795
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