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Invitrogen
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This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Translocating chain-associated membrane protein 2
基因别名: C330003D03Rik; Tram2
UniProt ID: (Mouse) Q924Z5
Entrez Gene ID: (Mouse) 170829