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Invitrogen
TRAP1 Polyclonal Antibody
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TRAP1 Antibody (PA5-30358) in ICC/IF
Immunofluorescence analysis of TRAP1 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with TRAP1 Polyclonal Antibody (Product # PA5-30358) at 5 microgram/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A2703... View More
产品信息
PA5-30358
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the N-terminus region of human TRAP1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Mouse (91%), Rat (90%), Zebrafish (81%), Pig (91%), Chicken (88%), Chimpanzee (100%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The 90 kDa heat shock protein (hsp90) family of molecular chaperones is a highly conserved family of proteins that play an important physiological role. Hsp90 is involved in numerous cellular processes but is best known for its association with signal transduction machinery. A recently cloned homolog of hsp90 is the tumor necrosis factor receptor-associated protein (TRAP1). Like hsp90, TRAP1 is found to be associated with numerous proteins involved in diverse actions. Immunofluorescence data has shown TRAP1 to be localized in the mitochondria of mammalian cells. This observation and the fact that TRAP1 is shown to have a mitochondrial targeting presequence strongly implicates TRAP1 as a mitochondrial matrix protein.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Heat shock protein 75 kDa, mitochondrial; Heat shock protein family C member 5; HSP 75; testicular tissue protein Li 209; TNF receptor-associated protein 1; TNFR-associated protein 1; TRAP-1; Tumor necrosis factor type 1 receptor-associated protein
基因别名: 2410002K23Rik; HSP 75; HSP75; HSP90L; HSPC5; TRAP-1; TRAP1
UniProt ID: (Human) Q12931, (Mouse) Q9CQN1
Entrez Gene ID: (Human) 10131, (Mouse) 68015
response to stress
translational attenuation
chaperone-mediated protein folding
negative regulation of cellular respiration
negative regulation of reactive oxygen species biosynthetic process
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
protein folding
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
