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Invitrogen
TRIB1 Polyclonal Antibody
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产品信息
PA5-142804
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence PEHVSPKARCLIRS.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
靶标信息
TRIB1 also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: TRB-1; trib1; Tribbles homolog 1
基因别名: A530090O15Rik; TRB-1; Trb1; Trib1
UniProt ID: (Mouse) Q8K4K4
Entrez Gene ID: (Mouse) 211770
protein kinase activity
protein kinase inhibitor activity
ATP binding
transcription factor binding
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity
non-receptor serine/threonine protein kinase
protein phosphorylation
negative regulation of protein kinase activity
JNK cascade
negative regulation of smooth muscle cell migration
negative regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
response to lipopolysaccharide
regulation of MAP kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of smooth muscle cell proliferation
regulation of catalytic activity
positive regulation of ubiquitin-protein transferase activity
