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Invitrogen
TRIB3 Polyclonal Antibody
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产品信息
PA5-96319
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human TRIB3 (NP_0669812)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.55 mg/mL
规格
55 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: 293T, SK-HEP1, K-562, SKOV3, BT-474, Mouse liver; Cellular Location: Nucleus
Immunogen sequence: MRATPLAAPA GSLSRKKRLE LDDNLDTERP VQKRARSGPQ PRLPPCLLPL SPPTAPDRAT AVATASRLGP YVLLEPEEGG RAYQALHCPT GTEYTCKVYP VQEALAVLEP YARLPPHKHV ARPTEVLAGT
靶标信息
A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DJ1103G7.3; induced in fatty liver dystrophy 2; Neuronal cell death-inducible putative kinase; TRB-3; Tribbles 3; Tribbles homolog 3
基因别名: Ifld2; Nipk; SINK; SKIP3; TRB-3; Trb3; Trib3
UniProt ID: (Mouse) Q8K4K2
Entrez Gene ID: (Mouse) 228775
transcription corepressor activity
protein kinase activity
protein kinase inhibitor activity
protein binding
ATP binding
transferase activity, transferring phosphorus-containing groups
enzyme binding
protein kinase binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity
non-receptor serine/threonine protein kinase
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of protein kinase activity
apoptotic process
regulation of glucose transport
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
response to endoplasmic reticulum stress
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of nucleic acid-templated transcription
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