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Invitrogen
TRIF Polyclonal Antibody
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TRIF Antibody (PA5-95104) in WB
Western blot analysis of TRIF in Lane 1: recombinant mouse TICAM1 protein (10 ng), Lane 2: recombinant mouse TICAM1 protein (5 ng), Lane 3: recombinant mouse TICAM1 protein (2.5 ng), Lane 4: recombinant mouse TICAM1 protein (1.25 ng). Samples were incubated with TRIF polyclonal antibody (Product # PA5-95104).
产品信息
PA5-95104
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of mouse TRIF (693-708aa NNHMWGHTGAQSSDDK).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hCG_39321; HSD34; RNF36; TI; TICAM-1; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
基因别名: AW046014; AW547018; TICAM-1; Ticam1; TRIF
UniProt ID: (Mouse) Q80UF7
Entrez Gene ID: (Mouse) 106759
macrophage activation involved in immune response
immune system process
MyD88-independent toll-like receptor signaling pathway
apoptotic process
inflammatory response
signal transduction
positive regulation of B cell proliferation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of protein binding
positive regulation of type I interferon production
response to lipopolysaccharide
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
regulation of protein homodimerization activity
positive regulation of chemokine biosynthetic process
innate immune response
positive regulation of interferon-beta biosynthetic process
positive regulation of nitric oxide biosynthetic process
positive regulation of B cell activation
positive regulation of NF-kappaB transcription factor activity
defense response to virus
apoptotic signaling pathway
