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Proteintech
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Immunogen sequence: MNGQLDLSG KLIIKAQLGE DIRRIPIHNE DITYDELVLM MQRVFRGKLL SNDEVTIKYK DEDGDLITIF DSSDLSFAIQ CSRILKLTLF VNGQPRPLES SQVKYLRREL IELRNKVNRL LDSLEPPGEP GPSTNIPEND TVDGREEKSA SDSSGKQSTQ VMAASMSAFD PLKNQDEINK NVMSAFGLTD DQVSGPPSAP AEDRSGTPDS IASSSSAAHP PGVQPQQPPY TGAQTQAGQI EGQMYQQYQQ QAGYGAQQPQ APPQQPQQYG IQYSASYSQQ TGPQQPQQFQ GYGQQPTSQA PAPAFSGQPQ QLPAQPPQQY QASNYPAQTY TAQTSQPTNY TVAPASQPGM APSQPGAYQP RPGFTSLPGS TMTPPPSGPN PYARNRPPFG QGYTQPGPGY R (1-400 aa encoded by BC023599)
TFG protein, a recently identified novel protein, is a human homolog of mouse TFG protein. It contains an N-terminal coiled-coil structure, a SPYGQ-rich region followed by octicosapeptide repeats. Research shows that TFG can modulate SHP-1 activity and is a novel member of the NF-kB pathway. The physiological functions of this protein remain largely elusive, but TFG is thought to function by associating with other proteins, including TANK and NEMO. TFG was first identified as a partner of NTRK1 and is involved in generating the thyroid TRK-T3 oncogene, as well as oncogenic rearrangements with ALK in anaplastic lymphoma and NOR1 in mixoid chondrosarcoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Protein TFG; TRK-fused gene protein; TRKT3 oncogene
基因别名: AI173908; HMSNP; SPG57; TF6; TFG; TRKT3
UniProt ID: (Human) Q92734
Entrez Gene ID: (Human) 10342, (Rat) 360709, (Mouse) 21787