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Alomone Labs, LTD
TRPA1 (extracellular) Polyclonal Antibody
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图: 1 / 5
TRPA1 (extracellular) Antibody (ACC-037-200UL) in ICC/IF
Expression of TRPA1 in rat PC12 cells - Cell surface detection of TRPA1 in intact living rat PC12 cells. A. Extracellular staining of cells using Anti-TRPA1 (extracellular) Antibody (#ACC-037), (1:50) followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Live view of the cells. C. Merged image of A and B.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
ACC-037-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)NSTGIINETSDHSE,corresponding to amino acid residues 747-760 of human TRPA1, 1st extracellular loop
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
规格
200 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ankyrin-like with transmembrane domains 1; ankyrin-like with transmembrane domains protein 1; cation channel; nompC; transformation-sensitive protein p120; transient receptor potential A1; transient receptor potential A1 ion channel; Transient Receptor Potential Ankyrin 1; TRPA-1; TRPA1; unnamed protein product; wasabi receptor
基因别名: ANKTM1; FEPS; FEPS1; p120; rTRPA1; TRPA1b
UniProt ID: (Human) O75762, (Mouse) Q8BLA8, (Rat) Q6RI86
Entrez Gene ID: (Human) 8989, (Mouse) 277328, (Rat) 312896
system process
ion transport
cellular calcium ion homeostasis
cell surface receptor signaling pathway
response to cold
urinary bladder smooth muscle contraction
sensory perception of pain
calcium-mediated signaling
cellular response to stress
cellular response to heat
positive regulation of insulin secretion involved in cellular response to glucose stimulus
vasodilation
thermoception
detection of chemical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception
protein homotetramerization
transmembrane transport
cellular response to hydrogen peroxide
cellular response to cold
calcium ion transmembrane transport
cellular response to food
cellular response to carbon dioxide
cellular response to caffeine
ureteric peristalsis
cellular response to toxic substance
calcium ion transmembrane import into cytosol
regulation of neuronal action potential
cellular response to oxygen-containing compound
regulation of blood circulation
positive regulation of monoatomic anion transport
calcium ion transport
response to xenobiotic stimulus
response to hydrogen peroxide
response to pain
detection of mechanical stimulus involved in sensory perception of pain
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