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TRPM4 Polyclonal Antibody
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产品信息
OST00345W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Goat
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from c-terminal region of rat transient receptor potential cation channel subfamily M member 4 (TRPM4) conjugated to an immunogenic carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPM4.
靶标信息
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Calcium-activated non-selective cation channel 1; H LTrpC-4; Long transient receptor potential channel 4; LTrpC-4; LTrpC4; melastatin like 2 protein; Melastatin-like 2; MLS2s; Transient receptor potential cation channel subfamily M member 4; transient receptor potential ion channel melastatin subgroup member 4
基因别名: 1110030C19Rik; AW047689; LTrpC-4; LTRPC4; Mls2s; Trpm4; TRPM4B
UniProt ID: (Mouse) Q7TN37, (Rat) Q9ESQ5
Entrez Gene ID: (Mouse) 68667, (Rat) 171143
immune system process
dendritic cell chemotaxis
regulation of T cell cytokine production
transport
ion transport
cation transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of heart rate
protein sumoylation
negative regulation of bone mineralization
ion transmembrane transport
regulation of ion transmembrane transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
vasoconstriction
regulation of membrane potential
positive regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of vasoconstriction
transmembrane transport
cardiac conduction
calcium ion transmembrane transport
positive regulation of canonical Wnt signaling pathway
cation transmembrane transport
positive regulation of atrial cardiac muscle cell action potential
