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Invitrogen
TSG Polyclonal Antibody
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TSG Antibody (PA5-47933) in IHC (F)
Immunohistochemical analysis of TSG in immersion fixed frozen sections of mouse embryo. Samples were incubated in TSG polyclonal antibody (Product # PA5-47933) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and t... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-47933
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Sf 21-derived recombinant mouse TSG Cys25-Phe222
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: involved in molecular signalling during spermatogenesis; secreted BMP-binding protein; twisted gastrulation homolog 1; unnamed protein product
基因别名: 1810013J15Rik; 9030422N06Rik; D17Ertd403e; Tsg; Twg
UniProt ID: (Mouse) Q9EP52
Entrez Gene ID: (Mouse) 65960
ossification
mesoderm formation
negative regulation of cytokine production
salivary gland morphogenesis
tissue development
hemopoiesis
cell differentiation
BMP signaling pathway
regulation of BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
forebrain development
camera-type eye development
negative regulation of osteoblast differentiation
positive regulation of SMAD protein import into nucleus
negative regulation of CD4-positive, alpha-beta T cell activation
negative regulation of CD4-positive, alpha-beta T cell proliferation
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
