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Abnova
TWSG1 Monoclonal Antibody (6E6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00057045-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG3, kappa
分类
Monoclonal
类型
Antibody
克隆号
6E6
抗原
TWSG1 (NP_065699, 124 a.a. approximately 223 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: AEELSHHENL VSFLETVNQP HHQNVSVPSN NVHAPYSSDK EHMCTVVYFD DCMSIHQCKI SCESMGASKY RWFHNACCEC IGPECIDYGS KTVKCMNCMF
靶标信息
TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: twisted gastrulation homolog 1; unnamed protein product
基因别名: TSG
UniProt ID: (Human) Q9GZX9
Entrez Gene ID: (Human) 57045
negative regulation of cytokine production
regulation of BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of SMAD protein import into nucleus
negative regulation of CD4-positive, alpha-beta T cell activation
negative regulation of CD4-positive, alpha-beta T cell proliferation
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