Proteintech

TYMS Monoclonal Antibody (1F5B7)

Name: TYMS Monoclonal Antibody (1F5B7)
Brand: Proteintech
SKU: 66725-1-IG

1 篇参考文献

查看其他33个Thymidylate Synthase抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (5)

TYMS Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 5

TYMS Antibody (66725-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 66725-1-Ig (TYMS antibody) at dilution of 1:500 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Immunogen image

Immunogen Image TYMS Monoclonal Antibody (1F5B7)

产品信息

66725-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000-1:10,000

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:250-1:1,000

流式细胞分析 (Flow)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1F5B7

抗原

TYMS Fusion Protein Ag7027 (1-313 aa encoded by BC002567)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MPVAGSELP RRPLPPAAQE RDAEPRPPHG ELQYLGQIQH ILRCGVRKDD RTGTGTLSVF GMQARYSLRD EFPLLTTKRV FWKGVLEELL WFIKGSTNAK ELSSKGVKIW DANGSRDFLD SLGFSTREEG DLGPVYGFQW RHFGAEYRDM ESDYSGQGVD QLQRVIDTIK TNPDDRRIIM CAWNPRDLPL MALPPCHALC QFYVVNSELS CQLYQRSGDM GLGVPFNIAS YALLTYMIAH ITGLKPGDFI HTLGDAHIYL NHIEPLKIQL QREPRPFPKL RILRKVEKID DFKAEDFQIE GYNPHPTIKM EMAV (1-313 aa encoded by BC002567)

靶标信息

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

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