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Alomone Labs, LTD
TYRO3 (extracellular) Polyclonal Antibody
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TYRO3 (extracellular) Antibody (ATR-031-200UL) in WB
Western blot analysis of human THP-1 monocytic leukemia cell line lysate (lanes 1 and 3) and human K562 chronic myelogenous leukemia cell line lysate (lanes 2 and 4). 1-2: Anti-TYRO3 (extracellular) Antibody (#ATR-031) (1:200). 3-4: Anti-TYRO3 (extracellular) Antibody, preincubated with TYRO3 (extracellular) Blocking Peptide (BLP-TR031).
产品信息
ATR-031-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide RLAYQGQDTPEVLMD, corresponding to amino acid residues 368-382 of human AXL. Extracellular, N-term.
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
规格
160 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: RLAYQGQDTPEVLMD
Reconstitution: 50 uL double distilled water (DDW). The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bruton agammaglobulinemia tyrosine kinase; Etk2/tyro3; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; TK19-2; tyro 3; TYRO3; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; unnamed protein product
基因别名: AI323366; Brt; BYK; DTK; Etk-2; etk2/tyro3; Rek; RSE; SKY; TIF; TK19-2; TYRO3
UniProt ID: (Human) Q06418, (Mouse) P55144, (Rat) P55146
Entrez Gene ID: (Human) 7301, (Mouse) 22174, (Rat) 25232
nucleotide binding
virus receptor activity
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
phosphatidylinositol 3-kinase binding
transferase activity, transferring phosphorus-containing groups
protein heterodimerization activity
transmembrane signal receptor
neuron migration
natural killer cell differentiation
phagocytosis
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
neuropeptide signaling pathway
spermatogenesis
nervous system development
cell migration
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
lymphocyte activation
viral entry into host cell
negative regulation of inflammatory response
negative regulation of lymphocyte activation
neuron apoptotic process
establishment of localization in cell
positive regulation of protein kinase B signaling
vagina development
neuron cellular homeostasis
platelet aggregation
positive regulation of viral life cycle
protein phosphorylation
phosphorylation
peptidyl-tyrosine phosphorylation
protein autophosphorylation
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