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Invitrogen
Tadalafil Recombinant Mouse Monoclonal Antibody (2E12)
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Tadalafil Antibody (MA566295) in SDS-PAGE
SDS-PAGE characterization of Tadalafil under reducing conditions. Lane M: Protein marker (kDa); Lane TDL: Purified Tadalafil Recombinant Monoclonal (Product # MA566295). Tadalafil showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-629.
产品信息
MA566295
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2E12
抗原
Conjugate of TDL hapten and KLH.
偶联物
形式
Liquid
浓度
2.7 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor primarily used for the treatment of erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. It functions by inhibiting the PDE5 enzyme, which results in increased levels of cyclic guanosine monophosphate (cGMP) leading to smooth muscle relaxation and vasodilation in the corpus cavernosum and pulmonary vasculature. Tadalafil is synthesized through various chemical routes, and its analogues have been developed to enhance its pharmacological profile. The gene location and structure are not directly applicable as tadalafil is a synthetic compound rather than a biological molecule. However, its mechanism of action involves interaction with the PDE5 enzyme, which is encoded by the PDE5A gene located on chromosome 4q27. Tadalafil's efficacy and safety have been demonstrated in clinical studies, particularly in combination with tamsulosin for improved management of lower urinary tract symptoms associated with benign prostatic hyperplasia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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