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Invitrogen
Tetrahydrocannabinol Recombinant Mouse Monoclonal Antibody (2B1)
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Tetrahydrocannabinol Antibody (MA566285) in SDS-PAGE
SDS-PAGE characterization of Tetrahydrocannabinol under reducing conditions. Lane M: Protein marker (kDa); Lane THC: Purified Tetrahydrocannabinol Recombinant Monoclonal (Product # MA566285). Tetrahydrocannabinol showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-345.
产品信息
MA566285
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2B1
抗原
Conjugate of THC hapten and KLH.
偶联物
形式
Liquid
浓度
2.5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Tetrahydrocannabinol (THC), specifically delta 9-THC, is the primary psychoactive component of Cannabis sativa, interacting predominantly with the cannabinoid receptors CB1 and CB2. CB1 receptors are highly expressed in the brain, mediating the psychoactive effects of THC, while CB2 receptors are more associated with immune function. Structurally, THC is a lipophilic molecule, allowing it to easily cross the blood-brain barrier and bind to CB1 receptors, leading to altered neurotransmitter release and psychoactive effects. THC analogs have been studied for their therapeutic potential, targeting CB1 receptors for various conditions. Additionally, THC undergoes metabolism to form psychoactive and non-psychoactive metabolites, such as 11-hydroxy-THC and 11-nor-9-carboxy-THC, which have implications for its pharmacokinetics and effects. The structural basis of THC's activity at the CB1 receptor has been elucidated, highlighting critical ligand interactions for potency and efficacy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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