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Invitrogen
Tick-Borne Encephalitis Virus NS4A Recombinant Rabbit Monoclonal Antibody (HL4155)
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Tick-Borne Encephalitis Virus NS4A Antibody (MA568424) in WB
Western blot analysis of Tick-Borne Encephalitis Virus NS4A in Non-transfected (–) and transfected (+) 293T whole cell extracts. Samples were incubated with Tick-Borne Encephalitis Virus NS4A recombinant monoclonal antibody (Product # MA568424) using a dilution of 1:5,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA568424
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL4155
抗原
Synthetic peptide of Tick-borne encephalitis virus NS4A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Tick-Borne Encephalitis Virus (TBEV) non-structural protein 4A (NS4A) is a small hydrophobic protein that plays a critical role in the virus's lifecycle. NS4A is involved in the rearrangement of cellular membranes, facilitating the formation of replication organelles necessary for viral RNA synthesis. It acts as a cofactor for the NS3 helicase, enhancing its ATPase activity, which is essential for unwinding viral RNA during replication. NS4A also contributes to the assembly of the viral replication complex, providing a scaffold that induces membrane curvature. Additionally, NS4A has been implicated in inhibiting interferon signaling, thereby modulating the host immune response to favor viral persistence. Research on NS4A focuses on its structural and functional dynamics to understand how it supports viral replication and immune evasion, offering potential targets for antiviral therapeutics. Inhibiting NS4A's interactions and functions may provide a strategy for controlling TBEV infection and reducing the severity of the disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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