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Invitrogen
TrkA Polyclonal Antibody
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产品信息
PA5-95139
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of mouse TrkA (71-90aa LYVENQQHLQRLEFEDLQGL).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Brain Tissue, Mouse Brain Tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp781I14186; EC 2.7.10.1; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A
基因别名: C80751; Ntrk1; Tkr; Trk; TrkA
UniProt ID: (Mouse) Q3UFB7, (Rat) P35739
Entrez Gene ID: (Mouse) 18211, (Rat) 59109
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
neurotrophin receptor activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase binding
protein homodimerization activity
ephrin receptor binding
nerve growth factor binding
transmembrane signal receptor
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
nervous system development
axon guidance
learning or memory
programmed cell death involved in cell development
response to activity
phosphorylation
peptidyl-tyrosine phosphorylation
sensory perception of pain
cell differentiation
B cell differentiation
response to nutrient levels
response to nicotine
nerve growth factor signaling pathway
mechanoreceptor differentiation
response to drug
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
sympathetic nervous system development
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of NF-kappaB transcription factor activity
response to electrical stimulus
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
innervation
axonogenesis involved in innervation
behavioral response to formalin induced pain
cellular response to nicotine
cellular response to growth factor stimulus
negative regulation of neuron death
cellular response to nerve growth factor stimulus
aging
circadian rhythm
negative regulation of cell proliferation
response to radiation
positive regulation of neuron projection development
olfactory nerve development
response to ethanol
positive regulation of Ras protein signal transduction
response to axon injury
response to hydrostatic pressure
positive regulation of ERK1 and ERK2 cascade
