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Invitrogen
UCP2 Recombinant Rabbit Monoclonal Antibody (PSH19-75)
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UCP2 Antibody (MA571402) in WB
Western blot was performed UCP2 Recombinant Rabbit Monoclonal Antibody (PSH19-75) (Product # MA571402) and bands at ~35 kDa and ~40 kDa corresponding to UCP2 were observed in the tested cell line models. Whole cell extracts (30 µg lysate) of Daudi (Lane 1), Jeko-1 (Lane 2), Raji (Lane 3), HeLa (Lane 4), MCF7 (Lane 5), MCF 10A (Lane 6) and HT-1080 (Lane 7) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB33001) by iBlot™ 3... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA571402
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH19-75
抗原
Synthetic peptide within human UCP2 aa 181-230.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.2% ProClin 950
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells, which reduces production of reactive oxygen species (ROS). The exact mechanisms of anion transfer by UCPs are not known. UCPs contain the three homologous protein domains of MACPs. Although it was originally thought to play a role in non-shivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species.
靶标信息
UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: mitochondrial uncoupling protein 2; solute carrier family 25 member 8; uncoupling protein; uncoupling protein 2 (mitochondrial, proton carrier)
基因别名: BMIQ4; SLC25A8; UCPH
UniProt ID: (Human) P55851
Entrez Gene ID: (Human) 7351
long-chain fatty acid transporter activity
protein binding
secondary active sulfate transmembrane transporter activity
hydrogen ion transmembrane transporter activity
chloride transmembrane transporter activity
oxaloacetate transmembrane transporter activity
malate transmembrane transporter activity
L-aspartate transmembrane transporter activity
antiporter activity
oxidative phosphorylation uncoupler activity
GDP binding
protein homodimerization activity
phosphate ion uniporter activity
mitochondrial fission
response to superoxide
response to hypoxia
glycolytic process
glutamine metabolic process
mitochondrial transport
response to cold
response to glucose
C4-dicarboxylate transport
long-chain fatty acid transport
macrophage differentiation
cellular response to insulin stimulus
cellular response to hormone stimulus
cellular response to amino acid starvation
negative regulation of apoptotic process
regulation of mitochondrial membrane potential
transmembrane transport
negative regulation of insulin secretion involved in cellular response to glucose stimulus
response to fatty acid
L-aspartate transmembrane transport
cellular response to lead ion
cellular response to glucose stimulus
malate transmembrane transport
response to dexamethasone
reactive oxygen species metabolic process
liver regeneration
negative regulation of calcium import into the mitochondrion
positive regulation of cold-induced thermogenesis
oxaloacetate(2-) transmembrane transport
sulfate transmembrane transport
chloride transmembrane transport
hydrogen ion transmembrane transport
mitochondrial transmembrane transport
adaptive thermogenesis
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