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Proteintech
UNC13A Recombinant Rabbit Monoclonal Antibody (240017A6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
83000-5-RR
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
240017A6
抗原
Peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
靶标信息
UNC13A, also named as KIAA1032, belongs to the unc-13 family. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. UNC13A is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. UNC13A is also involved in secretory granule priming in insulin secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: unnamed protein product
基因别名: 2410078G03Rik; IDDSF; Munc13-1; NEDHES; NEDSMS; Unc13h1
UniProt ID: (Human) Q9UPW8, (Mouse) Q4KUS2, (Rat) Q62768
Entrez Gene ID: (Human) 23025, (Pig) 100627038, (Mouse) 382018, (Rat) 64829
chemical synaptic transmission
neurotransmitter secretion
synaptic vesicle priming
synaptic transmission, glutamatergic
regulation of synaptic transmission, glutamatergic
dense core granule priming
neuronal dense core vesicle exocytosis
positive regulation of dendrite extension
positive regulation of neurotransmitter secretion
neuromuscular junction development
regulation of synaptic vesicle priming
synaptic vesicle exocytosis
synaptic vesicle maturation
positive regulation of vesicle fusion
positive regulation of synaptic plasticity
SNARE complex assembly
regulation of short-term neuronal synaptic plasticity
beta-amyloid metabolic process
long-term synaptic potentiation
innervation
regulation of calcium-dependent activation of synaptic vesicle fusion
positive regulation of glutamate receptor signaling pathway
regulation of amyloid precursor protein catabolic process
modulation of synaptic transmission
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