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Invitrogen
UNG2 Polyclonal Antibody
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产品信息
PA5-34551
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide near the amino terminus of human UNG2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is NIH-3T3 cell lysate.
PA5-34551 can be used with blocking peptide PEP-1594.
靶标信息
The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promoters and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: UDG; UDG2; UNG; Uracil-DNA glycosylase; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; uracil-DNA glycosylase nuclear isoform
基因别名: DGU; HIGM4; HIGM5; UDG; UNG; UNG1; UNG15; UNG2
UniProt ID: (Human) P13051, (Mouse) P97931
Entrez Gene ID: (Human) 7374, (Mouse) 22256
damaged DNA binding
uracil DNA N-glycosylase activity
protein binding
enzyme binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
uridine nucleosidase activity
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
DNA repair
base-excision repair
viral process
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
negative regulation of apoptotic process
depyrimidination
positive regulation of isotype switching
base-excision repair, AP site formation via deaminated base removal
cellular response to DNA damage stimulus
metabolic process
