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Proteintech
USP11 Polyclonal Antibody
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产品信息
10244-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
USP11 Fusion Protein Ag0296 (55-567 aa encoded by BC000350)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: RAGESWFLV EKHWYKQWEA YVQGGDQDSS TFPGCINNAT LFQDEINWRL KEGLVEGEDY VLLPAAAWHY LVSWYGLEHG QPPIERKVIE LPNIQKVEVY PVELLLVRHN DLGKSHTVQF SHTDSIGLVL RTARERFLVE PQEDTRLWAK NSEGSLDRLY DTHITVLDAA LETGQLIIME TRKKDGTWPS AQLHVMNNNM SEEDEDFKGQ PGICGLTNLG NTCFMNSALQ CLSNVPQLTE YFLNNCYLEE LNFRNPLGMK GEIAEAYADL VKQAWSGHHR SIVPHVFKNK VGHFASQFLG YQQHDSQELL SFLLDGLHED LNRVKKKEYV ELCDAAGRPD QEVAQEAWQN HKRRNDSVIV DTFHGLFKST LVCPDCGNVS VTFDPFCYLS VPLLISHKRV LEVFFIPMDP RRKPEQHRLV VPKKGKISDL CVALSKHTGI SPERMMVADV FSHRFYKLYQ LEEPLSSILD RDDIFVYEVS GRIEAIEGSR EDIVVPVYLR ERTPARDYNN SYYG (55-567 aa encoded by BC000350)
靶标信息
USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: deubiquitinating enzyme 11; RP4-659F15.2; ubiquitin carboxyl-terminal hydrolase, X-linked; ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; ubiquitin-specific-processing protease 11
基因别名: UHX1
Entrez Gene ID: (Human) 8237
