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Proteintech
USP49 Polyclonal Antibody
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产品信息
18066-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
USP49 Fusion Protein Ag12697 (1-352 aa encoded by BC014176)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDRCKHVGR LRLAQDHSIL NPQKWCCLEC ATTESVWACL KCSHVACGRY IEDHALKHFE ETGHPLAMEV RDLYVFCYLC KDYVLNDNPE GDLKLLRSSL LAVRGQKQDT PVRRGRTLRS MASGEDVVLP QRAPQGQPQM LTALWYRRQR LLARTLRLWF EKSSRGQAKL EQRRQEEALE RKKEEARRRR REVKRRLLEE LASTPPRKSA RLLLHTPRDA GPAASRPAAL PTSRRVPAAT LKLRRQPAMA PGVTGLRNLG NTCYMNSILQ VLSHLQKFRE CFLNLDPSKT EHLFPKATNG KTQLSGKPTN SSATELSLRN DRAEACEREG FCWNGRASIS RSLELIQNKE PSS (1-352 aa encoded by BC014176)
靶标信息
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Deubiquitinating enzyme 49; Ubiquitin carboxyl-terminal hydrolase 49; ubiquitin specific protease 49; Ubiquitin thioesterase 49; ubiquitin thiolesterase 49; Ubiquitin-specific-processing protease 49
基因别名: C330046L10Rik; Gm545; RGD1310513; USP49
UniProt ID: (Human) Q70CQ1, (Mouse) Q6P9L4
Entrez Gene ID: (Human) 25862, (Mouse) 224836, (Rat) 316211
mRNA splicing, via spliceosome
ubiquitin-dependent protein catabolic process
protein deubiquitination
histone H2B conserved C-terminal lysine deubiquitination
mRNA processing
proteolysis
RNA splicing
chromatin modification
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
