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Invitrogen
VAV1/2/3 Recombinant Rabbit Monoclonal Antibody (24GB2645)
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VAV1/2/3 Antibody (MA5-57313) in ICC/IF
Immunocytochemical staining of VAV1/2/3 in HepG2 cells using VAV1/2/3 Recombinant Monoclonal Antibody (Product # MA5-57313) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; Vav1/2/3 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
产品信息
MA5-57313
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
24GB2645
抗原
A synthesized peptide derived from human Vav1/2/3 (aa 750-800)
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
The VAV gene family consists of three members: VAV1, VAV2, and VAV3, which are guanine nucleotide exchange factors (GEFs) primarily involved in signal transduction. VAV1, located on chromosome 19p13.2, is predominant in hematopoietic cells and plays a crucial role in T and B lymphocyte signaling, impacting immune responses and cell cycle control. This gene has been implicated in autoimmune diseases as well as several cancers. VAV2, found on chromosome 9q34.1, is ubiquitously expressed and is involved in various cellular processes, such as DNA repair mechanisms and vascular smooth muscle function, with significant implications in cancer where overexpression correlates with tumor progression. VAV3, located on chromosome 1p13.3, shares similar GEF roles and is actively involved in oncogenic processes by mediating Rho GTPase signaling, affecting cell proliferation, migration, and invasion, and is considered a target for cancer therapy. The structural conservation and functional diversity of these proteins underscore their importance in both normal cellular function and disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Guanine nucleotide exchange factor VAV2; Guanine nucleotide exchange factor VAV3; Proto-oncogene vav; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav 2 guanine nucleotide exchange factor; vav 2 oncogene; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-2; VAV-3
基因别名: VAV; VAV-2; VAV1; VAV2; VAV3
UniProt ID: (Human) P15498, (Human) P52735, (Human) Q9UKW4
Entrez Gene ID: (Human) 7409, (Human) 7410, (Human) 10451
transcription factor activity, sequence-specific DNA binding
guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
protein binding
Rac guanyl-nucleotide exchange factor activity
metal ion binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
epidermal growth factor receptor binding
SH3/SH2 adaptor activity
GTPase activator activity
angiogenesis
vesicle fusion
cellular response to DNA damage stimulus
integrin-mediated signaling pathway
small GTPase mediated signal transduction
regulation of cell size
positive regulation of signal transduction
lamellipodium assembly
platelet activation
neutrophil chemotaxis
positive regulation of B cell proliferation
regulation of Rho protein signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
response to drug
positive regulation of apoptotic process
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of cell adhesion
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
B cell receptor signaling pathway
regulation of small GTPase mediated signal transduction
regulation of transcription, DNA-templated
immune response
G-protein coupled receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
T cell differentiation
T cell costimulation
positive regulation of natural killer cell mediated cytotoxicity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
reactive oxygen species metabolic process
signal transduction
regulation of gene expression
cell migration
regulation of blood coagulation
