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Proteintech
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Immunogen sequence: KCGARAHKEC LGRVDNCGRV NSGEQGTLKL PEKRTNGLRR TPKQVDPGLP KMQVIRNYSG TPPPALHEGP PLQLQAGDTV ELLKGDAHSL FWQGRNLASG EVGFFPSDAV KPCPCVPKPV DYSCQPWYAG AMERLQAETE LINRVNSTYL VRHRTKESGE YAISIKYNNE AKHIKILTRD GFFHIAENRK FKSLMELVEY YKHHSLKEGF RTLDTTLQFP YKEPEHSAGQ RGNRAGNSLL SPKVLGIAIA RYDFCARDMR ELSLLKGDVV KIYTKMSANG WWRGEVNGRV GWFPSTYVEE DE
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
基因别名: VAV3
UniProt ID: (Human) Q9UKW4
Entrez Gene ID: (Human) 10451