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Invitrogen
VAV3 Polyclonal Antibody
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VAV3 Antibody (PA5-143789) in WB
Western blot of VAV3 in human Jurkat (lanes 1 & 4), HUVEC (lanes 2 & 5), and A431 (lanes 3 & 6) cells. The blots were probed with anti-Vav2 (a.a. 309-322) at a dilution of 1:500 (lanes 1-3) and VAV3 polyclonal antibody (Product # PA5-143789) at a dilution of 1:500 (lanes 4-6).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-143789
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide (coupled to KLH) corresponding to amino acid residues in the Dbl homology domain of human Vav3. This sequence has high homology with similar regions in rat and mouse Vav3, and has low homology to other Vav family members.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects a 98 kDa* protein corresponding to the molecular mass of Vav3 on SDS-PAGE immunoblots of human Jurkat cells. The antibody also strongly detects an unidentified protein at 120 kDa in Jurkat and K562.
靶标信息
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ40431; guanosine nucleotide exchange factor; putative signal transduction molecule; unnamed protein product; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
基因别名: A530094I06Rik; Idd18.1; RGD1565941
UniProt ID: (Human) Q9UKW4, (Mouse) Q9R0C8
Entrez Gene ID: (Human) 10451, (Rat) 295378, (Mouse) 57257
immune response-regulating cell surface receptor signaling pathway
vesicle fusion
cellular response to DNA damage stimulus
cell surface receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
response to xenobiotic stimulus
cell migration
lamellipodium assembly
neutrophil chemotaxis
positive regulation of B cell proliferation
intracellular signal transduction
positive regulation of cell adhesion
B cell receptor signaling pathway
positive regulation of protein kinase B signaling
platelet activation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of small GTPase mediated signal transduction
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