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Invitrogen
VEGF Receptor 3 Polyclonal Antibody
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产品信息
PA1-24889
产品规格
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant, extracellular domain of human VEGFR3, expressed in mouse myeloma NSO cells.
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-24889 detects VEGF Receptor 3 from human samples.
PA1-24889 has been successfully used in Western blot procedures.
The PA1-24889 immunogen is recombinant, extracellular domain of human VEGFR3, expressed in mouse myeloma NSO cells.
靶标信息
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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