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Bethyl Laboratories
VISTA Polyclonal Antibody
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VISTA Antibody (A305-659A-T) in IP
Detection of human VISTA by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-VISTA antibody A305-659A-M (lot A305-659A-M-1) used for IP at 8 µl per reaction. VISTA was also immunoprecipitated by rabbit anti-VISTA antibody BL22641. For blotting immunoprecipitated VISTA, A305-659A-M was used at 1:250. Detection: Chemiluminescence with an exposure time of 3 mi... View More
产品信息
A305-659A-T
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Between 261 and 311
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.40 mg/mL
规格
8 µg
保存条件
4°C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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