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Abnova
VPS53 Polyclonal Antibody, MaxPab™
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产品信息
H00055275-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
VPS53 (NP_060759, 1 a.a. approximately 670 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MMEEEELEFV EELEAVLQLT PEVQLAIEQV FPSQDPLDRA DFNAVEYINT LFPTEQSLAN IDEVVNKIRL KIRRLDDNIR TVVRGQTNVG QDGRQVKEIT RDIKQLDHAK RHLTTSITTL NHLHMLAGGV DSLEAMTRRR QYGEVANLLQ GVMNVLEHFH KYMGIPQIRQ LSERVKAAQT ELGQQILADF EEAFPSQGTK RPGGPSNVLR DACLVANILD PRIKQEIIKK FIKQHLSEYL VLFQENQDVA WLDKIDRRYA WIKRQLVDYE EKYGRMFPRE WCMAERIAVE FCHVTRAELA KIMRTRAKEI EVKLLLFAIQ RTTNFEGFLA KRFSGCTLTD GTLKKLESPP PSTNPFLEDE PTPEMEELAT EKGDLDQPKK PKAPDNPFHG IVSKCFEPHL YVYIESQDKN LGELIDRFVA DFKAQGPPKP NTDEGGAVLP SCADLFVYYK KCMVQCSQLS TGEPMIALTT IFQKYLREYA WKILSGNLPK TTTSSGGLTI SSLLKEKEGS EVAKFTLEEL CLICNILSTA EYCLATTQQL EEKLKEKVDV SLIERINLTG EMDTFSTVIS SSIQLLVQDL DAACDPALTA MSKMQWQNVE HVGDQSPYVT SVILHIKQNV PIIRDNLAST RKYFTQFCVK FANSFIPKFI THLFKCKPIS MVGAEQVRWT
靶标信息
The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Vacuolar protein sorting-associated protein 53 homolog; VPS53 GARP complex subunit
基因别名: HCCS1; hVps53L; PCH2E; PP13624; VPS53
UniProt ID: (Human) Q5VIR6
Entrez Gene ID: (Human) 55275
