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Proteintech
VWF/VWFpp Polyclonal Antibody
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产品信息
11778-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
VWF, VWFpp Fusion Protein Ag2386 (1-273 aa encoded by .)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody raised against the N-terminal region of pre-pro-vWF recognizes von Willebrand antigen 2 (75-100 kDa) and pro-vWF (309-320 kDa).
Immunogen sequence: MGAQDEEEG IQDLDGLLVF DKIVEVTLLN LPWYNEETEG QRGEMTAPKS PRAKIRGTLC AEGTRGRSST ARCSLFGSDF VNTFDGSMYS FAGYCSYLLA GGCQKRSFSI IGDFQNGKRV SLSVYLGEFF DIHLFVNGTV TQGDQRVSMP YASKGLYLET EAGYYKLSGE AYGFVARIDG SGNFQVLLSD RYFNKTCGLC GNFNIFAEDD FMTQEGTLTS DPYDFANSWA LSSGEQWCER ASPPSSSCNI SSGEMQKVGV DWPGCTWMVC DFWI (1-273 aa encoded by .)
靶标信息
Von Willebrand factor (vWf) is a series of self-aggregated structures, all derived from common glycoprotein subunits, synthesized in endothelial cells and megakaryocytes. The molecular mass of the monomeric vWf unit is 225 kDa. vWf binds to circulating factor VIIIc (antihemophilic factor), hereby stabilizing the latter thus being an important factor in the normal primary haemostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Coagulation Factor VIII; coagulation factor VIII VWF; factor viii related antigen; von Willebrand Disease (vWD); von Willebrand factor; vWF; vwf {ECO:0000312|EMBL:CAB37852.1}
基因别名: 6820430P06Rik; AI551257; B130011O06Rik; C630030D09; F8VWF; VWD; VWF
UniProt ID: (Human) P04275, (Mouse) Q8CIZ8
Entrez Gene ID: (Human) 7450, (Mouse) 22371, (Rat) 116669
platelet degranulation
cell adhesion
blood coagulation
blood coagulation, intrinsic pathway
hemostasis
response to wounding
platelet activation
extracellular matrix organization
cell-substrate adhesion
response to immobilization stress
protein homooligomerization
liver development
placenta development
tissue regeneration
