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Invitrogen
Viperin Polyclonal Antibody
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Product Details
PA5-23508
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 165-215 of human viperin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen is 100% homologous in white-cheeked gibbon, chinese hamster, common chimpanzee, new world monkey, panda, african bush elephant and orangutan, 95% in horse, wild turkey, opossum, platypus, 89% in western clawed frog, rabbit, zebra finch, chicken, 79% in carolina anole, and 63% homologous in zebrafish and sablefish.
Target Information
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bone-expressed sequence tag 5 protein; Cytomegalovirus-induced gene 5 protein; Inflammatory response gene 6 protein; inflammatory response protein 6; IRG6; radical S-adenosyl methionine domain containing 2; Radical S-adenosyl methionine domain-containing protein 2; RSAD2; rsad2 {ECO:0000250|UniProtKB:Q8WXG1}; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; SAND; VHSV-induced-like protein; Viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Gene Aliases: 2510004L01Rik; Best5; cig33; CIG5; CIG6; IRG6; RSAD2; Vig1; viperin
UniProt ID: (Pig) Q9MZU4, (Bovine) Q2HJF9, (Human) Q8WXG1, (Rat) O70600, (Mouse) Q8CBB9
response to virus
positive regulation of toll-like receptor 7 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
CD4-positive, alpha-beta T cell activation
CD4-positive, alpha-beta T cell differentiation
innate immune response
negative regulation of protein secretion
defense response to virus
positive regulation of T-helper 2 cell cytokine production
ossification
metabolic process
regulation of ossification
negative regulation of viral genome replication
immune system process
type I interferon signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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