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Invitrogen
WAC Polyclonal Antibody
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WAC Antibody (PA5-85683) in IHC (P)
WAC Polyclonal Antibody detects WAC protein at nucleus in mouse testis by immunohistochemical analysis. Sample: Paraffin-embedded mouse testis. WAC Polyclonal Antibody (Product # PA5-85683) diluted at 1:1,000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
PA5-85683
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human WAC.
偶联物
形式
Liquid
浓度
0.35 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (94%), Rat (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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